Cyclin D as a therapeutic target in cancer

EA Musgrove, CE Caldon, J Barraclough… - Nature Reviews …, 2011 - nature.com
EA Musgrove, CE Caldon, J Barraclough, A Stone, RL Sutherland
Nature Reviews Cancer, 2011nature.com
Cyclin D1, and to a lesser extent the other D-type cyclins, is frequently deregulated in cancer
and is a biomarker of cancer phenotype and disease progression. The ability of these
cyclins to activate the cyclin-dependent kinases (CDKs) CDK4 and CDK6 is the most
extensively documented mechanism for their oncogenic actions and provides an attractive
therapeutic target. Is this an effective means of targeting the cyclin D oncogenes, and how
might the patient subgroups that are most likely to benefit be identified?
Abstract
Cyclin D1, and to a lesser extent the other D-type cyclins, is frequently deregulated in cancer and is a biomarker of cancer phenotype and disease progression. The ability of these cyclins to activate the cyclin-dependent kinases (CDKs) CDK4 and CDK6 is the most extensively documented mechanism for their oncogenic actions and provides an attractive therapeutic target. Is this an effective means of targeting the cyclin D oncogenes, and how might the patient subgroups that are most likely to benefit be identified?
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