Loss of the retinoblastoma tumor suppressor correlates with improved outcome in patients with lung adenocarcinoma treated with surgery and chemotherapy
The retinoblastoma tumor suppressor pathway is frequently inactivated in human cancer,
enabling unrestrained proliferation. Most cancers, however, maintain expression of a wild-
type (WT) retinoblastoma tumor suppressor protein (pRB). It is generally in a
hyperphosphorylated state (ppRB) because of mutations in upstream regulators such as p16
and cyclin D. Hyperphosphorylated ppRB is considered inactive, although data are
emerging that suggest it can retain some function. To test the clinical relevance of pRB …
enabling unrestrained proliferation. Most cancers, however, maintain expression of a wild-
type (WT) retinoblastoma tumor suppressor protein (pRB). It is generally in a
hyperphosphorylated state (ppRB) because of mutations in upstream regulators such as p16
and cyclin D. Hyperphosphorylated ppRB is considered inactive, although data are
emerging that suggest it can retain some function. To test the clinical relevance of pRB …