G-CSF was among the first cytokines to be identified and rapidly transitioned into clinical
medicine. Initially used to promote the production of neutrophils in patients with
chemotherapy-induced neutropenia it helped to revolutionize the delivery of cancer therapy.
Its ability to mobilize hematopoietic stem cells from the bone marrow into the blood was
subsequently exploited, changing the face of hematopoietic stem cell transplantation. Today
the knowledge gained in unraveling the mechanisms of stem cell mobilization by G-CSF is …