Neural stem cells: mechanisms and modeling

J Yao, Y Mu, FH Gage - Protein & cell, 2012 - academic.oup.com
J Yao, Y Mu, FH Gage
Protein & cell, 2012academic.oup.com
In the adult brain, neural stem cells have been found in two major niches: the hippocampus
and the olfactory bulb. Neurons derived from these stem cells contribute to learning,
memory, and the autonomous repair of the brain under pathological conditions. Hence, the
physiology of adult neural stem cells has become a significant component of research on
synaptic plasticity and neuronal disorders. In addition, the recently developed induced
pluripotent stem cell technique provides a powerful tool for researchers engaged in the …
Abstract
In the adult brain, neural stem cells have been found in two major niches: the hippocampus and the olfactory bulb. Neurons derived from these stem cells contribute to learning, memory, and the autonomous repair of the brain under pathological conditions. Hence, the physiology of adult neural stem cells has become a significant component of research on synaptic plasticity and neuronal disorders. In addition, the recently developed induced pluripotent stem cell technique provides a powerful tool for researchers engaged in the pathological and pharmacological study of neuronal disorders. In this review, we briefly summarize the research progress in neural stem cells in the adult brain and in the neuropathological application of the induced pluripotent stem cell technique.
Oxford University Press