[HTML][HTML] Aggressive melanoma cells escape from BMP7-mediated autocrine growth inhibition through coordinated Noggin upregulation
MY Hsu, SA Rovinsky, CY Lai, S Qasem, X Liu… - Laboratory …, 2008 - Elsevier
Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily responsible for
mediating a diverse array of cellular functions both during embryogenesis and in adult life.
Previously, we reported that upregulation of BMP7 in human melanoma correlates with
tumor progression. However, melanoma cells are either inhibited by or become resistant to
BMP7 as a function of tumor progression, with normal melanocytes being most susceptible.
Herein, real-time quantitative reverse transcriptase-polymerase chain reactions and western …
mediating a diverse array of cellular functions both during embryogenesis and in adult life.
Previously, we reported that upregulation of BMP7 in human melanoma correlates with
tumor progression. However, melanoma cells are either inhibited by or become resistant to
BMP7 as a function of tumor progression, with normal melanocytes being most susceptible.
Herein, real-time quantitative reverse transcriptase-polymerase chain reactions and western …