[HTML][HTML] Active gene repression by the Egr2· NAB complex during peripheral nerve myelination

GM Mager, RM Ward, R Srinivasan, SW Jang… - Journal of biological …, 2008 - ASBMB
The Egr2/Krox20 transactivator is required for activation of many myelin-associated genes
during peripheral nerve myelination by Schwann cells. However, recent work has indicated
that Egr2 not only activates genes required for peripheral nerve myelination but may also be
involved in gene repression. The NAB (NGFI-A/Egr-binding) corepressors interact with Egr2
and are required for proper coordination of myelin formation. Therefore, NAB proteins could
mediate repression of some Egr2 target genes, although direct repression by Egr2 or NAB …