Acquired aplastic anemia (aAA) is a nonmalignant disease caused by autoimmune
destruction of early hematopoietic cells. Clonal hematopoiesis is a late complication, seen in
20–25% of older patients. We hypothesized that clonal hematopoiesis in aAA is a more
general phenomenon, which can arise early in disease, even in younger patients. To
evaluate clonal hematopoiesis in aAA, we used comparative whole exome sequencing of
paired bone marrow and skin samples in 22 patients. We found somatic mutations in 16 …