Rare occurrence of a STAT5B N642H mutation in adult T-cell acute lymphoblastic leukemia
X Ma, L Wen, L Wu, Q Wang, H Yao… - Cancer …, 2015 - cancergeneticsjournal.org
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy that accounts for
approximately 15% of pediatric and 25% of adult ALL cases. T-ALL is caused by the
accumulation of multiple oncogenic mutations that have been identified through the
characterization of chromosomal aberrations and candidate gene sequencing (1). STAT5
has an important role in many hematologic malignancies, but constitutive activation is often
a secondary event (2). STAT5B (signal transducer and activator of transcription 5B), a …
approximately 15% of pediatric and 25% of adult ALL cases. T-ALL is caused by the
accumulation of multiple oncogenic mutations that have been identified through the
characterization of chromosomal aberrations and candidate gene sequencing (1). STAT5
has an important role in many hematologic malignancies, but constitutive activation is often
a secondary event (2). STAT5B (signal transducer and activator of transcription 5B), a …