[HTML][HTML] MicroRNA-21 promotes glioblastoma tumorigenesis by down-regulating insulin-like growth factor-binding protein-3 (IGFBP3)
CH Yang, J Yue, SR Pfeffer, M Fan, E Paulus… - Journal of biological …, 2014 - ASBMB
Despite advances in surgery, imaging, chemotherapy, and radiation, patients with
glioblastoma multiforme (GBM), the most common histological subtype of glioma, have an
especially dismal prognosis;> 70% of GBM patients die within 2 years of diagnosis. In many
human cancers, the microRNA miR-21 is overexpressed, and accumulating evidence
indicates that it functions as an oncogene. Here, we report that miR-21 is overexpressed in
human GBM cell lines and tumor tissue. Moreover, miR-21 expression in GBM patient …
glioblastoma multiforme (GBM), the most common histological subtype of glioma, have an
especially dismal prognosis;> 70% of GBM patients die within 2 years of diagnosis. In many
human cancers, the microRNA miR-21 is overexpressed, and accumulating evidence
indicates that it functions as an oncogene. Here, we report that miR-21 is overexpressed in
human GBM cell lines and tumor tissue. Moreover, miR-21 expression in GBM patient …