The endoplasmic reticulum (ER) and mitochondria cannot be considered as static structures,
as they intimately communicate, forming very dynamic platforms termed mitochondria-
associated membranes (MAMs). In particular, the ER transmits proper Ca 2+ signals to
mitochondria, which decode them into specific inputs to regulate essential functions,
including metabolism, energy production and apoptosis. Here, we will describe the different
molecular players involved in the transfer of Ca 2+ ions from the ER lumen to the …