Automating tumor classification with pixel-by-pixel contrast-enhanced ultrasound perfusion kinetics
CN Ta, Y Kono, CV Barback, RF Mattrey… - Journal of Vacuum …, 2012 - pubs.aip.org
Contrast-enhanced ultrasound (CEUS) enables highly specific time-resolved imaging of
vasculature by intravenous injection of∼ 2 μm gas filled microbubbles. To develop a
quantitative automated diagnosis of breast tumors with CEUS, breast tumors were induced
in rats by administration of N-ethyl-N-nitrosourea. A bolus injection of microbubbles was
administered and CEUS videos of each tumor were acquired for at least 3 min. The time-
intensity curve of each pixel within a region of interest (ROI) was analyzed to measure …
vasculature by intravenous injection of∼ 2 μm gas filled microbubbles. To develop a
quantitative automated diagnosis of breast tumors with CEUS, breast tumors were induced
in rats by administration of N-ethyl-N-nitrosourea. A bolus injection of microbubbles was
administered and CEUS videos of each tumor were acquired for at least 3 min. The time-
intensity curve of each pixel within a region of interest (ROI) was analyzed to measure …