[HTML][HTML] SOX9 regulates low density lipoprotein receptor-related protein 6 (LRP6) and T-cell factor 4 (TCF4) expression and Wnt/β-catenin activation in breast cancer
Gene expression profiling has identified breast cancer (BCa) subtypes, including an
aggressive basal-like (BL) subtype. The molecular signals underlying the behavior observed
in BL-BCa group are largely unknown, although recent results indicate a prevalent increase
in Wnt/β-catenin activity. Our immunohistochemistry study confirmed that SOX9, one of the
BL-BCa signature genes, was expressed by most BL-BCa, and its expression correlated
with indicators of poor prognosis. Importantly, BCa gene expression profiling strongly …
aggressive basal-like (BL) subtype. The molecular signals underlying the behavior observed
in BL-BCa group are largely unknown, although recent results indicate a prevalent increase
in Wnt/β-catenin activity. Our immunohistochemistry study confirmed that SOX9, one of the
BL-BCa signature genes, was expressed by most BL-BCa, and its expression correlated
with indicators of poor prognosis. Importantly, BCa gene expression profiling strongly …