Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores

GKT Chan, SA Jablonski, DA Starr, ML Goldberg… - Nature cell …, 2000 - nature.com
GKT Chan, SA Jablonski, DA Starr, ML Goldberg, TJ Yen
Nature cell biology, 2000nature.com
Here we show that human Zeste White 10 (Zw10) and Rough deal (Rod) are new
components of the mitotic checkpoint, as cells lacking these proteins at kinetochores fail to
arrest in mitosis when exposed to microtubule inhibitors. Checkpoint failure and premature
mitotic exit may explain why cells defective for hZw10 and hRod divide with lagging
chromosomes. As Zw10 and Rod are not conserved in yeast, our data, combined with an
accompanying study of Drosophila Zw10 and Rod, indicate that metazoans may require an …
Abstract
Here we show that human Zeste White 10 (Zw10) and Rough deal (Rod) are new components of the mitotic checkpoint, as cells lacking these proteins at kinetochores fail to arrest in mitosis when exposed to microtubule inhibitors. Checkpoint failure and premature mitotic exit may explain why cells defective for hZw10 and hRod divide with lagging chromosomes. As Zw10 and Rod are not conserved in yeast, our data, combined with an accompanying study of Drosophila Zw10 and Rod, indicate that metazoans may require an elaborate spindle checkpoint to monitor complex kinetochore functions.
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