Immunohistochemistry for ERG expression as a surrogate for TMPRSS2-ERG fusion detection in prostatic adenocarcinomas
A Chaux, R Albadine, A Toubaji, J Hicks… - The American journal …, 2011 - journals.lww.com
Background TMPRSS2-ERG fusions have been identified in about one-half of all prostatic
adenocarcinomas (PCas). Fluorescence in situ hybridization (FISH) and reverse
transcription polymerase chain reaction have been the most commonly used techniques in
this setting. The aim of this study was to evaluate the utility of ERG immunoexpression as a
surrogate for TMPRSS2-ERG fusion in a large series of PCa cases. Materials and Methods
Four hundred twenty-seven radical retropubic prostatectomy tissue samples were used to …
adenocarcinomas (PCas). Fluorescence in situ hybridization (FISH) and reverse
transcription polymerase chain reaction have been the most commonly used techniques in
this setting. The aim of this study was to evaluate the utility of ERG immunoexpression as a
surrogate for TMPRSS2-ERG fusion in a large series of PCa cases. Materials and Methods
Four hundred twenty-seven radical retropubic prostatectomy tissue samples were used to …