The ever-expanding role of HIF in tumour and stromal biology
EL LaGory, AJ Giaccia - Nature cell biology, 2016 - nature.com
EL LaGory, AJ Giaccia
Nature cell biology, 2016•nature.comLow oxygen tension (hypoxia) is a hallmark of cancer that influences cancer cell function,
but is also an important component of the tumour microenvironment as it alters the
extracellular matrix, modulates the tumour immune response and increases angiogenesis.
Here we discuss the regulation and role of hypoxia and its key transcriptional mediators, the
hypoxia-inducible factor (HIF) family of transcription factors, in the tumour microenvironment
and stromal compartments.
but is also an important component of the tumour microenvironment as it alters the
extracellular matrix, modulates the tumour immune response and increases angiogenesis.
Here we discuss the regulation and role of hypoxia and its key transcriptional mediators, the
hypoxia-inducible factor (HIF) family of transcription factors, in the tumour microenvironment
and stromal compartments.
Abstract
Low oxygen tension (hypoxia) is a hallmark of cancer that influences cancer cell function, but is also an important component of the tumour microenvironment as it alters the extracellular matrix, modulates the tumour immune response and increases angiogenesis. Here we discuss the regulation and role of hypoxia and its key transcriptional mediators, the hypoxia-inducible factor (HIF) family of transcription factors, in the tumour microenvironment and stromal compartments.
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