[HTML][HTML] Antibody-targeted vaccination to lung dendritic cells generates tissue-resident memory CD8 T cells that are highly protective against influenza virus infection
Influenza virus gains entry into the body by inhalation and initiates its replication cycle within
the lung. The early stage of infection, while the virus is confined to the lung mucosa,
provides the ideal window of opportunity for an effective immune response to control the
infection. Tissue-resident memory (Trm) CD8 T cells, located in a variety of tissues including
the lung, are ideally situated to act during this window and stall the infection. The factors
involved in the differentiation of lung Trm cells remain poorly defined. We demonstrate that …
the lung. The early stage of infection, while the virus is confined to the lung mucosa,
provides the ideal window of opportunity for an effective immune response to control the
infection. Tissue-resident memory (Trm) CD8 T cells, located in a variety of tissues including
the lung, are ideally situated to act during this window and stall the infection. The factors
involved in the differentiation of lung Trm cells remain poorly defined. We demonstrate that …