Transient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B
C Boni, A Penna, A Bertoletti, V Lamonaca, I Rapti… - Journal of …, 2003 - Elsevier
Background/Aims: Lamivudine therapy in patients with chronic hepatitis B can induce the
recovery of antiviral T cell responses. It is unknown whether the recovery of T cell
responsiveness is long-lasting and persists throughout the treatment and whether the
elevation of viremia which follows therapy withdrawal can restore a condition of T cell
unresponsiveness. Methods: Frequency and function of circulating hepatitis B virus (HBV)-
specific CD4 and CD8 cells from 12 hepatitis e surface antigen+ patients with chronic …
recovery of antiviral T cell responses. It is unknown whether the recovery of T cell
responsiveness is long-lasting and persists throughout the treatment and whether the
elevation of viremia which follows therapy withdrawal can restore a condition of T cell
unresponsiveness. Methods: Frequency and function of circulating hepatitis B virus (HBV)-
specific CD4 and CD8 cells from 12 hepatitis e surface antigen+ patients with chronic …