[HTML][HTML] The Alzheimer's disease peptide β‐amyloid promotes thrombin generation through activation of coagulation factor XII
D Zamolodchikov, T Renné, S Strickland - Journal of Thrombosis and …, 2016 - Elsevier
Essentials• How the Alzheimer's disease (AD) peptide β‐amyloid (Aβ) disrupts neuronal
function in the disease is unclear.• Factor (F) XII initiates blood clotting via FXI, and
thrombosis has been implicated in AD.• Aβ triggers FXII‐dependent FXI and thrombin
activation, evidence of which is seen in AD plasma.• Aβ‐triggered clotting could contribute to
neuronal dysfunction in AD and be a novel therapeutic target. Summary: Background β‐
Amyloid (Aβ) is a key pathologic element in Alzheimer's disease (AD), but the mechanisms …
function in the disease is unclear.• Factor (F) XII initiates blood clotting via FXI, and
thrombosis has been implicated in AD.• Aβ triggers FXII‐dependent FXI and thrombin
activation, evidence of which is seen in AD plasma.• Aβ‐triggered clotting could contribute to
neuronal dysfunction in AD and be a novel therapeutic target. Summary: Background β‐
Amyloid (Aβ) is a key pathologic element in Alzheimer's disease (AD), but the mechanisms …