[HTML][HTML] Chronic mild cerebrovascular dysfunction as a cause for Alzheimer's disease?
C Humpel - Experimental gerontology, 2011 - Elsevier
Alzheimer's disease (AD) is a progressive chronic disorder and is characterized by β-
amyloid plaques and angiopathy, tau pathology, neuronal cell death, and inflammatory
responses. The reasons for this disease are not known. This review proposes the hypothesis
that a chronic mild longlasting cerebrovascular dysfunction could initiate a cascade of
events leading to AD. It is suggested that (vascular) risk factors (eg hypercholesterolemia,
type 2 diabetes, hyperhomocysteinemia) causes either damage of the cerebrovascular …
amyloid plaques and angiopathy, tau pathology, neuronal cell death, and inflammatory
responses. The reasons for this disease are not known. This review proposes the hypothesis
that a chronic mild longlasting cerebrovascular dysfunction could initiate a cascade of
events leading to AD. It is suggested that (vascular) risk factors (eg hypercholesterolemia,
type 2 diabetes, hyperhomocysteinemia) causes either damage of the cerebrovascular …