[HTML][HTML] Plasmin deficiency leads to fibrin accumulation and a compromised inflammatory response in the mouse brain
K Hultman, M Cortes‐Canteli, A Bounoutas… - Journal of Thrombosis …, 2014 - Elsevier
Background Excess fibrin in blood vessels is cleared by plasmin, the key proteolytic enzyme
in fibrinolysis. Neurological disorders and head trauma can result in the disruption of the
neurovasculature and the entry of fibrin and other blood components into the brain, which
may contribute to further neurological dysfunction. Objectives While chronic fibrin deposition
is often implicated in neurological disorders, the pathological contributions attributable
specifically to fibrin have been difficult to ascertain. An animal model that spontaneously …
in fibrinolysis. Neurological disorders and head trauma can result in the disruption of the
neurovasculature and the entry of fibrin and other blood components into the brain, which
may contribute to further neurological dysfunction. Objectives While chronic fibrin deposition
is often implicated in neurological disorders, the pathological contributions attributable
specifically to fibrin have been difficult to ascertain. An animal model that spontaneously …