[HTML][HTML] GluN3A: an NMDA receptor subunit with exquisite properties and functions
LA Kehoe, Y Bernardinelli, D Muller - Neural plasticity, 2013 - hindawi.com
LA Kehoe, Y Bernardinelli, D Muller
Neural plasticity, 2013•hindawi.comN-methyl-D-aspartate receptors (NMDAR) are pivotal for synaptic plasticity and memory
formation. Conventional NMDAR consist of heterotetrameric structures composed of GluN1
and GluN2 subunits. A third subunit, GluN3, can also assemble with NMDAR subunits giving
a remarkable modification of their heteromeric structure, forming a “nonconventional”
NMDAR. As a consequence, the stoichiometry and kinetic properties of the receptors are
dramatically changed. Among the GluN3 family, the GluN3A subunit has been the focus of a …
formation. Conventional NMDAR consist of heterotetrameric structures composed of GluN1
and GluN2 subunits. A third subunit, GluN3, can also assemble with NMDAR subunits giving
a remarkable modification of their heteromeric structure, forming a “nonconventional”
NMDAR. As a consequence, the stoichiometry and kinetic properties of the receptors are
dramatically changed. Among the GluN3 family, the GluN3A subunit has been the focus of a …
N-methyl-D-aspartate receptors (NMDAR) are pivotal for synaptic plasticity and memory formation. Conventional NMDAR consist of heterotetrameric structures composed of GluN1 and GluN2 subunits. A third subunit, GluN3, can also assemble with NMDAR subunits giving a remarkable modification of their heteromeric structure, forming a “nonconventional” NMDAR. As a consequence, the stoichiometry and kinetic properties of the receptors are dramatically changed. Among the GluN3 family, the GluN3A subunit has been the focus of a large amount of studies during recent years. These studies reveal that GluN3A is transiently expressed during development and could play a role in the fine tuning of neuronal networks as well as associated diseases. Moreover, GluN3A distribution outside the postsynaptic densities, including perisynaptic astrocytes, places it at a strategic position to play an important role in the interactions between neurons and glial cells. This review highlights GluN3A properties and addresses its role in neurophysiology and associated pathologies.
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