ATP-binding cassette transporters are targets for the development of antibacterial vaccines and therapies

HS Garmory, RW Titball - Infection and immunity, 2004 - Am Soc Microbiol
HS Garmory, RW Titball
Infection and immunity, 2004Am Soc Microbiol
ATP-binding cassette (ABC) transporters are widespread among living organisms and
comprise one of the largest protein families. For example, components of ABC transporters
are encoded by approximately 5% of the Escherichia coli and Bacillus subtilis genomes (47,
80). These transporters are found in all species and are evolutionarily related. However,
they are functionally diverse and have roles in a wide range of important cellular functions.
The different ABC transporters can be assigned to classes, families and subfamilies on the …
ATP-binding cassette (ABC) transporters are widespread among living organisms and comprise one of the largest protein families. For example, components of ABC transporters are encoded by approximately 5% of the Escherichia coli and Bacillus subtilis genomes (47, 80). These transporters are found in all species and are evolutionarily related. However, they are functionally diverse and have roles in a wide range of important cellular functions. The different ABC transporters can be assigned to classes, families and subfamilies on the basis of phylogenetic analyses (19).
American Society for Microbiology