Cardiac arrhythmias are associated with abnormal channel function due to mutations in ion
channel genes. Epilepsy is a disorder of neuronal function also involving abnormal channel
function. It is increasingly demonstrated that the etiologies of long QT syndrome and
epilepsy may partly overlap. However, only a few genetic studies have addressed a possible
link between cardiac and neural channelopathies. We describe a family showing the
association between Brugada syndrome and epilepsy in which a known mutation in the …