Non-invasive system for applying airway obstructions to model obstructive sleep apnea in mice
A Carreras, Y Wang, D Gozal, JM Montserrat… - Respiratory physiology …, 2011 - Elsevier
Obstructive sleep apnea (OSA) is characterized by recurrent upper airway obstructions
during sleep. The most common animal model of OSA is based on subjecting rodents to
intermittent hypoxic exposures and does not mimic important OSA features, such as
recurrent hypercapnia and increased inspiratory efforts. To circumvent some of these issues,
a novel murine model involving non-invasive application of recurrent airway obstructions
was developed. An electronically controlled airbag system is placed in front of the mouse's …
during sleep. The most common animal model of OSA is based on subjecting rodents to
intermittent hypoxic exposures and does not mimic important OSA features, such as
recurrent hypercapnia and increased inspiratory efforts. To circumvent some of these issues,
a novel murine model involving non-invasive application of recurrent airway obstructions
was developed. An electronically controlled airbag system is placed in front of the mouse's …