INK4a/ARF: a multifunctional tumor suppressor locus
NE Sharpless - … Research/Fundamental and Molecular Mechanisms of …, 2005 - Elsevier
The INK4a/ARF locus encodes two physically linked tumor suppressor proteins, p16INK4a
and ARF, which regulate the RB and p53 pathways, respectively. The unusual genomic
relationship of the open reading frames of these proteins initially fueled speculation that only
one of the two was the true tumor suppressor, and loss of the other merely coincidental in
cancer. Recent human and mouse genetic data, however, have firmly established that both
proteins possess significant in vivo tumor suppressor activity, although there appear to be …
and ARF, which regulate the RB and p53 pathways, respectively. The unusual genomic
relationship of the open reading frames of these proteins initially fueled speculation that only
one of the two was the true tumor suppressor, and loss of the other merely coincidental in
cancer. Recent human and mouse genetic data, however, have firmly established that both
proteins possess significant in vivo tumor suppressor activity, although there appear to be …