The senescence-associated secretory phenotype: the dark side of tumor suppression

JP Coppé, PY Desprez, A Krtolica… - Annual review of …, 2010 - annualreviews.org
JP Coppé, PY Desprez, A Krtolica, J Campisi
Annual review of pathology: mechanisms of disease, 2010annualreviews.org
Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at
risk for malignant transformation. However, accumulating evidence shows that senescent
cells can have deleterious effects on the tissue microenvironment. The most significant of
these effects is the acquisition of a senescence-associated secretory phenotype (SASP) that
turns senescent fibroblasts into proinflammatory cells that have the ability to promote tumor
progression.
Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at risk for malignant transformation. However, accumulating evidence shows that senescent cells can have deleterious effects on the tissue microenvironment. The most significant of these effects is the acquisition of a senescence-associated secretory phenotype (SASP) that turns senescent fibroblasts into proinflammatory cells that have the ability to promote tumor progression.
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