Cellular senescence prevents the proliferation of cells at risk for neoplastic transformation.
Nonetheless, the senescence response is thought to be antagonistically pleiotropic and thus
contribute to aging phenotypes, including, ironically, late life cancers. The cancer-promoting
activity of senescent cells is likely due to secreted molecules, the identity of which remains
largely unknown. Here, we have shown that senescent fibroblasts, much more than
presenescent fibroblasts, stimulate tumor vascularization in mice. Weakly malignant …