LILRB1 polymorphism and surface phenotypes of natural killer cells
CL Davidson, NL Li, DN Burshtyn - Human Immunology, 2010 - Elsevier
Leukocyte Ig-like receptor (LIR)–1 is an inhibitory receptor that binds a broad range of class I
HLA molecules and is encoded by the LILRB1 gene within the leukocyte receptor complex.
In contrast to uniform expression on monocytes and B cells, LIR-1 expression on natural
killer (NK) cells varies considerably between individuals. To investigate how polymorphism
is related to the observed patterns of expression, we analyzed the LILRB1 gene and its
transcriptional activity in a group of individuals with various levels of expression on NK cells …
HLA molecules and is encoded by the LILRB1 gene within the leukocyte receptor complex.
In contrast to uniform expression on monocytes and B cells, LIR-1 expression on natural
killer (NK) cells varies considerably between individuals. To investigate how polymorphism
is related to the observed patterns of expression, we analyzed the LILRB1 gene and its
transcriptional activity in a group of individuals with various levels of expression on NK cells …