[HTML][HTML] Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma
PloS one, 2009•journals.plos.org
Background Non-small cell lung cancer (NSCLC) is the foremost cause of cancer-related
death in Western countries, which is due partly to the propensity of NSCLC cells to
metastasize. The biologic basis for NSCLC metastasis is not well understood.
Methodology/Principal Findings Here we addressed this deficiency by transcriptionally
profiling tumors from a genetic mouse model of human lung adenocarcinoma that develops
metastatic disease owing to the expression of K-rasG12D and p53R172H. We identified …
death in Western countries, which is due partly to the propensity of NSCLC cells to
metastasize. The biologic basis for NSCLC metastasis is not well understood.
Methodology/Principal Findings Here we addressed this deficiency by transcriptionally
profiling tumors from a genetic mouse model of human lung adenocarcinoma that develops
metastatic disease owing to the expression of K-rasG12D and p53R172H. We identified …
Background
Non-small cell lung cancer (NSCLC) is the foremost cause of cancer-related death in Western countries, which is due partly to the propensity of NSCLC cells to metastasize. The biologic basis for NSCLC metastasis is not well understood.
Methodology/Principal Findings
Here we addressed this deficiency by transcriptionally profiling tumors from a genetic mouse model of human lung adenocarcinoma that develops metastatic disease owing to the expression of K-rasG12D and p53R172H. We identified 2,209 genes that were differentially expressed in distant metastases relative to matched lung tumors. Mining of publicly available data bases revealed this expression signature in a subset of NSCLC patients who had a poorer prognosis than those without the signature.
Conclusions/Significance
These findings provide evidence that K-rasG12D; p53R172H mice recapitulate features of human NSCLC metastasis and will provide a useful platform on which to study the biologic basis for lung adenocarcinoma metastasis and its prevention by novel agents.
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