Animal models of DIC and their relevance to human DIC: a systematic review
LO Berthelsen, AT Kristensen, M Tranholm - Thrombosis research, 2011 - Elsevier
Disseminated intravascular coagulation (DIC) is a severe clinical condition with activation of
coagulation and fibrinolysis. Its diagnosis is based on the International Society of
Thrombosis and Haemostasis (ISTH) scoring system of DIC. Animal models of DIC, used to
investigate pathophysiology and evaluate treatments, have not been developed in a
standardized way, which impedes comparison between models and translation to the
human setting. In the current review of animal models of DIC an overview of species …
coagulation and fibrinolysis. Its diagnosis is based on the International Society of
Thrombosis and Haemostasis (ISTH) scoring system of DIC. Animal models of DIC, used to
investigate pathophysiology and evaluate treatments, have not been developed in a
standardized way, which impedes comparison between models and translation to the
human setting. In the current review of animal models of DIC an overview of species …