Cochlear abnormalities in insulin-like growth factor-1 mouse mutants
G Camarero, MA Villar, J Contreras… - Hearing research, 2002 - Elsevier
Insulin-like growth factor 1 (IGF-1) modulates inner ear cell proliferation, differentiation and
survival in culture. Its function in human hearing was first evidenced by a report of a boy with
a homozygous deletion of the Igf-1 gene, who showed severe sensorineural deafness
[Woods et al., New Engl. J. Med. 335 (1996) 1363–1367]. To better understand the in vivo
role of IGF-1 during inner ear differentiation and maturation, we studied the cochleae of Igf-1
gene knockout mice by performing morphometric stereological analyses …
survival in culture. Its function in human hearing was first evidenced by a report of a boy with
a homozygous deletion of the Igf-1 gene, who showed severe sensorineural deafness
[Woods et al., New Engl. J. Med. 335 (1996) 1363–1367]. To better understand the in vivo
role of IGF-1 during inner ear differentiation and maturation, we studied the cochleae of Igf-1
gene knockout mice by performing morphometric stereological analyses …