[HTML][HTML] Ultraviolet-induced junD activation and apoptosis in myeloblastic leukemia ML-1 cells

T Li, W Dai, L Lu - Journal of Biological Chemistry, 2002 - ASBMB
The exposure of mammalian cells to UV irradiation induces the expression of immediate
early genes such as c-jun and c-fos and activates the transcription factors AP-1 and NF-κB.
JunD is one of the three members of the Jun family and shares some functional
characteristics with c-Jun. In the present study, we found that the exposure of myeloblastic
leukemia ML-1 cells to UV light (UVC) caused a significant increase injunD mRNA
expression within 5 min that persisted for a period of 3 h. The activation of protein kinase C …