[HTML][HTML] Hepatic FoxOs regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase gene
FoxO transcription factors have been implicated in lipid metabolism; however, the underlying
mechanisms are not well understood. Here, in an effort to elucidate such mechanisms, we
examined the phenotypic consequences of liver-specific deletion of three members of the
FoxO family: FoxO1, FoxO3, and FoxO4. These liver-specific triply null mice, designated
LTKO, exhibited elevated triglycerides in the liver on regular chow diet. More remarkably,
LTKO mice developed severe hepatic steatosis following placement on a high fat diet …
mechanisms are not well understood. Here, in an effort to elucidate such mechanisms, we
examined the phenotypic consequences of liver-specific deletion of three members of the
FoxO family: FoxO1, FoxO3, and FoxO4. These liver-specific triply null mice, designated
LTKO, exhibited elevated triglycerides in the liver on regular chow diet. More remarkably,
LTKO mice developed severe hepatic steatosis following placement on a high fat diet …