[HTML][HTML] Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion
L Yu, S Gupta, F Xu, ADB Liverman, A Moschetta… - Journal of Biological …, 2005 - ASBMB
The major pathway for elimination of cholesterol in mammals is via secretion into bile. Biliary
cholesterol secretion is mediated by the ATP-binding cassette (ABC) transporters ABCG5
(G5) and ABCG8 (G8) and is stimulated by cholesterol and by the non-cholesterol steroids
cholate and diosgenin. To define the relationship between G5G8 expression and biliary
cholesterol secretion, we measured G5 and G8 mRNA levels and biliary cholesterol
concentrations in genetically manipulated mice expressing 0, 1, 2, 5, 10, or 16 copies of the …
cholesterol secretion is mediated by the ATP-binding cassette (ABC) transporters ABCG5
(G5) and ABCG8 (G8) and is stimulated by cholesterol and by the non-cholesterol steroids
cholate and diosgenin. To define the relationship between G5G8 expression and biliary
cholesterol secretion, we measured G5 and G8 mRNA levels and biliary cholesterol
concentrations in genetically manipulated mice expressing 0, 1, 2, 5, 10, or 16 copies of the …