[HTML][HTML] Vanilloid receptor 1 regulates multiple calcium compartments and contributes to Ca2+-induced Ca2+ release in sensory neurons
LJ Kárai, JT Russell, MJ Iadarola, Z Oláh - Journal of Biological Chemistry, 2004 - ASBMB
Vanilloid receptor 1 belongs to the transient receptor potential ion channel family and
transduces sensations of noxious heat and inflammatory hyperalgesia in nociceptive
neurons. These neurons contain two vanilloid receptor pools, one in the plasma membrane
and the other in the endoplasmic reticulum. The present experiments characterize these two
pools and their functional significance using calcium imaging and 45 Ca uptake in stably
transfected cells or dorsal root ganglion neurons. The plasma membrane localized receptor …
transduces sensations of noxious heat and inflammatory hyperalgesia in nociceptive
neurons. These neurons contain two vanilloid receptor pools, one in the plasma membrane
and the other in the endoplasmic reticulum. The present experiments characterize these two
pools and their functional significance using calcium imaging and 45 Ca uptake in stably
transfected cells or dorsal root ganglion neurons. The plasma membrane localized receptor …