Use of a novel thermal operant behavioral assay for characterization of orofacial pain sensitivity
JK Neubert, CG Widmer, W Malphurs, HL Rossi… - Pain, 2005 - Elsevier
Orofacial pain has been well-characterized clinically, but evaluation of orofacial pain in
animals has not kept pace. The objective of this study was to describe behavioral responses
to facial thermal stimulation and inflammation with/without an analgesic using a novel
operant paradigm. Animals were trained to voluntarily place their face against a stimulus
thermode (37.7–57.2° C) providing access to positive reinforcement. These contingencies
present a conflict between positive reward and tolerance for nociceptive stimulation …
animals has not kept pace. The objective of this study was to describe behavioral responses
to facial thermal stimulation and inflammation with/without an analgesic using a novel
operant paradigm. Animals were trained to voluntarily place their face against a stimulus
thermode (37.7–57.2° C) providing access to positive reinforcement. These contingencies
present a conflict between positive reward and tolerance for nociceptive stimulation …