Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia

TL Yaksh, DH Farb, SE Leeman, TM Jessell - Science, 1979 - science.org
TL Yaksh, DH Farb, SE Leeman, TM Jessell
Science, 1979science.org
Intrathecal Capsaicin Depletes Substance P in the Rat Spinal Cord and Produces
Prolonged Thermal Analgesia Page 1 platelet MAO activity reflects monoaminergic activity
in the tubero-infundibular system. JOEL E. KLEINMAN, STEVEN POTKIN Laboratory
ofClinical Psychopharmacology, Division of Special Mental Health Research, National
Institute ofMental Health, Saint Elizabeths Hospital, Washington, DC 20032 ALAN ROGOL
Department ofPediatrics, University of Virginia Medical Center, Charlottesville 22908 …
A single intrathecal injection of capsaicin depletes substance P from primary sensory neurons and causes a prolonged increase in the thermal and chemical pain thresholds of the rat but no apparent change in responses to noxious mechanical stimuli.
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