Correlation between senescence and DNA repair in cells from young and old individuals and in premature aging syndromes

H Weirich-Schwaiger, HG Weirich, B Gruber… - Mutation Research …, 1994 - Elsevier
Cellular aging appears to be related to and perhaps caused by diminished DNA repair. To
elucidate direct correlations between DNA repair capacity and senescence various
parameters of cellular aging and DNA repair were studied simultaneously. Of special
interest are features of DNA repair and senescence in cultured diploid fibroblasts derived
either from healthy young or elderly probands as well as from patients suffering from
premature senescence syndromes (Werner syndrome, Cockayne syndrome, ataxia …