β-Amyloid precursor polypeptide in SAMP8 mice affects learning and memory
Senescence accelerated (SAMP8 [P8]) mice develop age-related deficits in memory and
learning. We show that increased expression of amyloid precursor protein (APP) and its
mRNA in the hippocampus are also age-related. Immunocytochemical data suggest that a
critical amount of APP expression may be needed to generate amyloid (Aβ) protein plaques
in the hippocampus. Deficits in acquisition and retention test performance were alleviated by
administration of antibody to Aβ protein into the cerebral ventricles. This reversal of cognitive …
learning. We show that increased expression of amyloid precursor protein (APP) and its
mRNA in the hippocampus are also age-related. Immunocytochemical data suggest that a
critical amount of APP expression may be needed to generate amyloid (Aβ) protein plaques
in the hippocampus. Deficits in acquisition and retention test performance were alleviated by
administration of antibody to Aβ protein into the cerebral ventricles. This reversal of cognitive …
