Pulmonary Hypertension in Rats 2. Role of lnterleukin-6
M Miyata, F Sakuma, A Yoshimura… - International archives of …, 1995 - karger.com
M Miyata, F Sakuma, A Yoshimura, H Ishikawa, T Nishimaki, R Kasukawa
International archives of allergy and immunology, 1995•karger.comWe administered human interleukin (IL)-6 to rats to examine whether it is implicated in the
development of pulmonary hypertension (PH). The rats injected with IL-6 developed PH as
determined by the weight ratio of the right ventricle to the left ventricle+ septum. This ratio
decreased with the appearance of IgG anti-human IL-6 antibody. Histologically we observed
in the lungs, luminal occlusion of small muscular arteries, capillaries filled with fibrin thrombi,
and localized hemorrhage. IL-6 increased the number of platelets, and the number of …
development of pulmonary hypertension (PH). The rats injected with IL-6 developed PH as
determined by the weight ratio of the right ventricle to the left ventricle+ septum. This ratio
decreased with the appearance of IgG anti-human IL-6 antibody. Histologically we observed
in the lungs, luminal occlusion of small muscular arteries, capillaries filled with fibrin thrombi,
and localized hemorrhage. IL-6 increased the number of platelets, and the number of …
Abstract
We administered human interleukin (IL)-6 to rats to examine whether it is implicated in the development of pulmonary hypertension (PH). The rats injected with IL-6 developed PH as determined by the weight ratio of the right ventricle to the left ventricle+septum. This ratio decreased with the appearance of IgG anti-human IL-6 antibody. Histologically we observed in the lungs, luminal occlusion of small muscular arteries, capillaries filled with fibrin thrombi, and localized hemorrhage. IL-6 increased the number of platelets, and the number of platelets correlated with the extent of PH. Thus, it seems likely that (IL-6) is involved in the formation of PH in this model.
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