Epigenetic regulators: multifunctional proteins modulating hypoxia-inducible factor-α protein stability and activity
The hypoxia-inducible factor (HIF) is a heterodimeric transcription factor governing a
transcriptional program in response to reduced O 2 availability in metazoans. It contributes
to physiology and pathogenesis of many human diseases through its downstream target
genes. Emerging studies have shown that the transcriptional activity of HIF is highly
regulated at multiple levels and the epigenetic regulators are essential for HIF-mediated
transactivation. In this review, we will discuss the comprehensive regulation of HIF …
transcriptional program in response to reduced O 2 availability in metazoans. It contributes
to physiology and pathogenesis of many human diseases through its downstream target
genes. Emerging studies have shown that the transcriptional activity of HIF is highly
regulated at multiple levels and the epigenetic regulators are essential for HIF-mediated
transactivation. In this review, we will discuss the comprehensive regulation of HIF …
Abstract
The hypoxia-inducible factor (HIF) is a heterodimeric transcription factor governing a transcriptional program in response to reduced O2 availability in metazoans. It contributes to physiology and pathogenesis of many human diseases through its downstream target genes. Emerging studies have shown that the transcriptional activity of HIF is highly regulated at multiple levels and the epigenetic regulators are essential for HIF-mediated transactivation. In this review, we will discuss the comprehensive regulation of HIF transcriptional activity by different types of epigenetic regulators.
Springer