[HTML][HTML] E-Cadherin/β-Catenin Complex and the Epithelial Barrier
X Tian, Z Liu, B Niu, J Zhang, TK Tan, SR Lee… - BioMed Research …, 2011 - hindawi.com
X Tian, Z Liu, B Niu, J Zhang, TK Tan, SR Lee, Y Zhao, DCH Harris, G Zheng
BioMed Research International, 2011•hindawi.comE-Cadherin/β-catenin complex plays an important role in maintaining epithelial integrity and
disrupting this complex affect not only the adhesive repertoire of a cell, but also the Wnt-
signaling pathway. Aberrant expression of the complex is associated with a wide variety of
human malignancies and disorders of fibrosis resulting from epithelial-mesenchymal
transition. These associations provide insights into the complexity that is likely responsible
for the fibrosis/tumor suppressive action of E-cadherin/β-catenin.
disrupting this complex affect not only the adhesive repertoire of a cell, but also the Wnt-
signaling pathway. Aberrant expression of the complex is associated with a wide variety of
human malignancies and disorders of fibrosis resulting from epithelial-mesenchymal
transition. These associations provide insights into the complexity that is likely responsible
for the fibrosis/tumor suppressive action of E-cadherin/β-catenin.
E-Cadherin/β-catenin complex plays an important role in maintaining epithelial integrity and disrupting this complex affect not only the adhesive repertoire of a cell, but also the Wnt-signaling pathway. Aberrant expression of the complex is associated with a wide variety of human malignancies and disorders of fibrosis resulting from epithelial-mesenchymal transition. These associations provide insights into the complexity that is likely responsible for the fibrosis/tumor suppressive action of E-cadherin/β-catenin.
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