[HTML][HTML] Focal adhesion kinase (FAK) regulates insulin-stimulated glycogen synthesis in hepatocytes
D Huang, AT Cheung, JT Parsons… - Journal of Biological …, 2002 - ASBMB
Experimental data support a role for FAK, an important component of the integrin signaling
pathway, in insulin action. To test the hypothesis that FAK plays a regulatory role in hepatic
insulin action, we overexpressed wild type (WT), a kinase inactive (KR), or a COOH-terminal
focal adhesion targeting (FAT) sequence-truncated mutant of FAK in HepG2 hepatoma cells.
In control untransfected (NON) and vector (CMV2)-and WT-transfected cells, insulin
stimulated an expected 54±13, 37±4, and 47±12 increase in [U-14 C] glucose incorporation …
pathway, in insulin action. To test the hypothesis that FAK plays a regulatory role in hepatic
insulin action, we overexpressed wild type (WT), a kinase inactive (KR), or a COOH-terminal
focal adhesion targeting (FAT) sequence-truncated mutant of FAK in HepG2 hepatoma cells.
In control untransfected (NON) and vector (CMV2)-and WT-transfected cells, insulin
stimulated an expected 54±13, 37±4, and 47±12 increase in [U-14 C] glucose incorporation …