[HTML][HTML] Wnt signaling and hepatocarcinogenesis: molecular targets for the development of innovative anticancer drugs
F Pez, A Lopez, M Kim, JR Wands, CC de Fromentel… - Journal of …, 2013 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer death
worldwide. HCC can be cured by radical therapies if early diagnosis is done while the tumor
has remained of small size. Unfortunately, diagnosis is commonly late when the tumor has
grown and spread. Thus, palliative approaches are usually applied such as transarterial
intrahepatic chemoembolization and sorafenib, an anti-angiogenic agent and MAP kinase
inhibitor. This latter is the only targeted therapy that has shown significant, although …
worldwide. HCC can be cured by radical therapies if early diagnosis is done while the tumor
has remained of small size. Unfortunately, diagnosis is commonly late when the tumor has
grown and spread. Thus, palliative approaches are usually applied such as transarterial
intrahepatic chemoembolization and sorafenib, an anti-angiogenic agent and MAP kinase
inhibitor. This latter is the only targeted therapy that has shown significant, although …