Cross-presentation in mouse and human dendritic cells

E Segura, S Amigorena - Advances in immunology, 2015 - Elsevier
Cross-presentation designates the presentation of exogenous antigens on major
histocompatibility complex class I molecules and is essential for the initiation of cytotoxic
immune responses. It is now well established that dendritic cells (DCs) are the best cross-
presenting cells. In this chapter, we will discuss recent advances in our understanding of the
molecular mechanisms of cross-presentation. We will also describe the different DC subsets
identified in mouse and human, and their functional specialization for cross-presentation …