IL-4 selectively enhances FcγRIII expression and signaling on mouse mast cells
HJ Chong, LA Bouton, DP Bailey, H Wright… - Cellular …, 2003 - Elsevier
Fc receptors for IgG (FcγR) are widely expressed in the hematopoietic system and mediate a
variety of inflammatory responses. There are two functional classes of FcγR, activation and
inhibitory receptors. Since IgG immune complexes (IgG IC) bind each class with similar
affinity, co-expression of these receptors leads to their co-ligation. Thus, expression levels of
this antagonistic pair play a critical role in determining the cellular response. Murine mast
cells co-express the activation receptor FcγRIII and the inhibitory receptor FcγRIIb and can …
variety of inflammatory responses. There are two functional classes of FcγR, activation and
inhibitory receptors. Since IgG immune complexes (IgG IC) bind each class with similar
affinity, co-expression of these receptors leads to their co-ligation. Thus, expression levels of
this antagonistic pair play a critical role in determining the cellular response. Murine mast
cells co-express the activation receptor FcγRIII and the inhibitory receptor FcγRIIb and can …