[HTML][HTML] CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-κB activation pathways

L Bouchier-Hayes, H Conroy, H Egan, C Adrain… - Journal of Biological …, 2001 - ASBMB
Proteins possessing the caspase recruitment domain (CARD) motif have been implicated in
pathways leading to activation of caspases or NF-κB in the context of apoptosis or
inflammation, respectively. Here we report the identification of a novel protein, CARDINAL,
that contains a CARD motif and also exhibits a high degree of homology to the C terminus of
DEFCAP/NAC, a recently described member of the Apaf-1/Nod-1 family. In contrast with the
majority of CARD proteins described to date, CARDINAL failed to promote apoptosis or NF …