Interleukin-6-572C/G polymorphism is associated with serum interleukin-6 levels and risk of idiopathic pulmonary arterial hypertension
M Fang, Y Huang, Y Zhang, Z Ning, L Zhu… - Journal of the American …, 2017 - Elsevier
Abstract Interleukin 6 (IL-6) is a multifunctional proinflammatory cytokine that is elevated in
patients with pulmonary arterial hypertension (PAH). Single nucleotide polymorphisms in the
promoter region of IL-6 have been reported to transcriptional regulate the expression of IL-6.
The aim of the present study is to investigate the roles of two common polymorphisms (-
572C/G [rs1800796] and-6331T/C [rs10499563]) of IL-6 in idiopathic PAH (IPAH). A total of
338 IPAH patients and 352 age-and gender-matched healthy controls were enrolled …
patients with pulmonary arterial hypertension (PAH). Single nucleotide polymorphisms in the
promoter region of IL-6 have been reported to transcriptional regulate the expression of IL-6.
The aim of the present study is to investigate the roles of two common polymorphisms (-
572C/G [rs1800796] and-6331T/C [rs10499563]) of IL-6 in idiopathic PAH (IPAH). A total of
338 IPAH patients and 352 age-and gender-matched healthy controls were enrolled …