Pulmonary hypertension in patients with advanced heart failure is associated with increased levels of interleukin-6
J Dolenc, M Šebeštjen, B Vrtovec, M Koželj… - Biomarkers, 2014 - Taylor & Francis
Context: Inflammatory, endothelial and neurohormonal biomarkers are involved in heart
failure (HF) and pulmonary hypertension (PH) pathogenesis. Objective: To study these
biomarkers in PH due to advanced HF. Materials and methods: Thirty adults with HF were
included. Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive
protein (hsCRP), endothelin-1 and N-terminal prohormone of brain natriuretic peptide (NT-
proBNP) were measured in peripheral vein and pulmonary artery during right heart …
failure (HF) and pulmonary hypertension (PH) pathogenesis. Objective: To study these
biomarkers in PH due to advanced HF. Materials and methods: Thirty adults with HF were
included. Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive
protein (hsCRP), endothelin-1 and N-terminal prohormone of brain natriuretic peptide (NT-
proBNP) were measured in peripheral vein and pulmonary artery during right heart …
Abstract
Context: Inflammatory, endothelial and neurohormonal biomarkers are involved in heart failure (HF) and pulmonary hypertension (PH) pathogenesis.
Objective: To study these biomarkers in PH due to advanced HF.
Materials and methods: Thirty adults with HF were included. Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hsCRP), endothelin-1 and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) were measured in peripheral vein and pulmonary artery during right heart catheterisation.
Results: IL-6, TNF-α, hsCRP and NT-proBNP correlated with pulmonary pressures independent of ventricular function, HF etiology and vascular bed. IL-6 was independent predictor of systolic pulmonary artery pressure (sPAP).
Discussion and conclusion: Inflammatory biomarkers correlate to PH severity. IL-6 predicts sPAP in advanced HF.
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