Up-regulation of microRNA-210 induces immune dysfunction via targeting FOXP3 in CD4+ T cells of psoriasis vulgaris
M Zhao, L Wang, G Liang, P Zhang, X Deng, Q Tang… - Clinical …, 2014 - Elsevier
Psoriasis vulgaris (PV) is a chronic inflammatory and T cell-mediated autoimmune skin
disease. An immune dysfunction that is manifested by abnormally activated T cells and
defective regulatory T (Treg) cells may play an important role in the pathogenesis of PV.
However, the precise mechanism of the immune dysfunction in PV patients still remains
unclear. In this study, we found that miR-210 expression is increased significantly in CD4+ T
cells from patients with PV and confirmed that FOXP3 is a target gene of miR-210. We also …
disease. An immune dysfunction that is manifested by abnormally activated T cells and
defective regulatory T (Treg) cells may play an important role in the pathogenesis of PV.
However, the precise mechanism of the immune dysfunction in PV patients still remains
unclear. In this study, we found that miR-210 expression is increased significantly in CD4+ T
cells from patients with PV and confirmed that FOXP3 is a target gene of miR-210. We also …